PhD candidate combining hands-on wet-lab disease modeling with single-cell RNA-seq and quantitative proteomics. Author of 12+ JCR-Q1 publications (169+ citations, 3 first-author and 1 co-first-author papers, IF up to 14.6). Trained to design rigorous, multi-step experiments and interpret complex biological data — ready to create high-quality challenges and evaluate AI model reasoning in the life sciences.
Key Qualifications
Wet-lab + computation hybrid researcher
Multi-step experimental reasoning
Proteomics, transcriptomics, genomics
Active PhD with institutional affiliation
Protein assays: WB, ELISA, MS
R / Python bioinformatics pipelines
Research Experience
Graduate Researcher
2022 – Present
Sun Yat-sen University · School of Pharmaceutical Sciences
- Designed and executed multi-arm in-vivo studies on drug-induced cardiotoxicity and heart failure with rigorous controls, blinding, and reproducibility protocols
- Performed scRNA-seq and downstream computational analysis to map cell-type-specific injury mechanisms in cardiovascular disease models
- Integrated quantitative proteomics (LC-MS/MS) with histological and functional endpoints in chronic e-cigarette studies, identifying differentially expressed proteins and perturbed signaling pathways
- Developed therapeutic leads — cryptotanshinone derivative DST-3 for ischemic stroke, combining SAR-informed design with in-vivo neuroprotection assays
- Built bioinformatics pipelines (R, Python) for transcriptomic processing, differential expression, pathway enrichment, and multi-omics integration
- Validated computational findings at the bench via Western blot, ELISA, qRT-PCR, and IHC across cardiovascular, neurological, and fibrotic disease models
Selected Publications
- Zhang J, Dai Y (co-first), Yu J, Chen Y, et al. "SNX3 exacerbates hepatic fibrosis by amplifying TGF-β1/Smad signaling pathway in hepatocyte-HSC fibrotic loop." Acta Pharmaceutica Sinica B (2026). IF 14.6 Co-1st · DOI: 10.1016/j.apsb.2026.06.021
- Dai Y, Yu J, He G, et al. "DST-3 attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation." Phytomedicine 147, 157223 (2025). IF 11.3 1st Author · Cited: 2
- Dai Y, Yang W, Song H, et al. "Long-term effects of e-cigarette aerosol on cardiovascular and pulmonary systems: A comparative study to cigarette smoke." Environment International 185, 108521 (2024). IF 10.2 1st Author · Cited: 25 · incl. quantitative proteomics
- Dai Y, Duan K, Huang G, et al. "E-cigarette inhalation effects on lung function and inflammation in mice." Frontiers in Toxicology 5, 1232040 (2023). IF 5.1 1st Author · Cited: 13
+ 8 co-authored publications in JCR-Q1 journals incl. Phytomedicine (IF 11.3), BMC Public Health (64 cit.), Eur. J. Med. Chem. (IF 6.7), and others.
Open Source
XSTARS
Active Development
Open-source Excel add-in for automated statistics and publication-quality figures. VBA / Python ⭐ 11