I work at the interface of experimental pharmacology and computational biology, using single-cell RNA sequencing and multi-omics analysis to map injury mechanisms, then validating drug candidates at the bench. My primary focus is cardiovascular disease — from drug-induced cardiotoxicity to heart failure progression. On the translational side, I develop and evaluate natural-product derivatives (cryptotanshinone analogues, etc.) as therapeutic leads, and contribute to preclinical drug evaluation across cardiovascular, neurological, and fibrotic disease models.
🔬 Researcher
Author of 12+ peer-reviewed publications with 169+ citations (h-index: 5). First-author work published in Environment International (IF 10.2), Phytomedicine (IF 11.3), and other JCR-Q1 journals.
🛠️ Open Source
Building tools for bench researchers — currently developing XSTARS, an Excel add-in for automated statistics and publication-quality figures.
Analysis pipelines and reproducible code from published studies — coming soon.
🤝 Collaboration
Open to collaborations in cardiovascular pharmacology, multi-omics data analysis, and translational drug discovery. Whether you have a dataset that needs computational analysis or a drug candidate that needs in-vivo validation — let's talk.
🏫 Educations
🏆 Awards
📃 Publications
SNX3 exacerbates hepatic fibrosis by amplifying TGF-β1/Smad signaling pathway in hepatocyte-HSC fibrotic loop
Xueshuantong injection alleviates ischemic heart failure via targeting PFKP-mediated endothelial-to-mesenchymal transition
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation
Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke
Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice
Cigarettes smoking and e-cigarettes using among university students: a cross-section survey in Guangzhou, China, 2021
Cryptotanshinone alleviates lipopolysaccharide and cigarette smoke-induced chronic obstructive pulmonary disease in mice via the Keap1/Nrf2 axis
α-Ketoglutarate attenuates oxidative stress-induced neuronal aging via modulation of the mTOR pathway
Synthesis and anti-acute ischemic stroke effect of the quinazoline-benzothiazole RIPK1 inhibitors
DST-3, a Novel Modified Cryptotanshinone, Protects Against Pulmonary Fibrosis via Inhibiting STAT3/Smad Signaling Pathway and Improves Bioavailability
Design, synthesis, anti-acute ischemic stroke (AIS) effect of receptor-interacting protein kinase 1 (RIPK1) inhibitors containing quinazoline structure
Phytochemical Analysis and Neuroprotective Effect of Salvia castanea Diels f. Tomentosa Stib Extracts
🛠️ Projects
XSTARS
Active DevelopmentA free, open-source Excel add-in that automates statistical testing and generates publication-quality figures — designed so bench researchers can go from raw data to journal-ready visuals without writing a single line of code.
📬 Contact
Research Collaboration
Interested in collaborations on cardiovascular pharmacology, multi-omics analysis, or translational drug discovery.
Consulting
Available for consulting in data analysis (R/Python, bioinformatics), clinical research, and pharmaceutical science.